Redox regulation of autophagy in skeletal muscle
نویسندگان
چکیده
منابع مشابه
The regulation of autophagy during exercise in skeletal muscle.
The merits of exercise on muscle health and well-being are numerous and well documented. However, the mechanisms underlying the robust adaptations induced by exercise, particularly on mitochondria, are less clear and much sought after. Recently, an evolutionary conserved cellular recycling mechanism known as autophagy has been implicated in the adaptations to acute and chronic exercise. A basal...
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Changes in population demographics have seen an increase in human lifespan coupled with an increase in many age associated disorders that determine quality of life including, sarcopenia, and frailty. Closing the gap between life expectancy and healthy aging has now become a research priority in many countries. Skeletal muscle comprises up to 40% of body mass and the inhibition or delay of the p...
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Skeletal muscle has the ability to adapt and remodel after functional, mechanical, and metabolic stresses by activation of different adaptation mechanisms that induce gene expression, biochemical changes, and structural remodeling. Skeletal muscle cells continuously generate reactive oxygen and nitrogen species (RONS), which can act as mediators in cellular signaling pathways that regulate the ...
متن کاملRedox Characterization of Functioning Skeletal Muscle
Skeletal muscle physiology is influenced by the presence of chemically reactive molecules such as reactive oxygen species (ROS). These molecules regulate multiple redox-sensitive signaling pathways that play a critical role in cellular processes including gene expression and protein modification. While ROS have gained much attention for their harmful effects in muscle fatigue and dysfunction, r...
متن کاملRole of AMPK in regulation of LC3 lipidation as a marker of autophagy in skeletal muscle.
During induction of the autophagosomal degradation process, LC3-I is lipidated to LC3-II and associates to the cargo isolation membrane allowing for autophagosome formation. Lipidation of LC3 results in an increased LC3-II/LC3-I ratio, and this ratio is an often used marker for autophagy in various tissues, including skeletal muscle. From cell studies AMPK has been proposed to be necessary and ...
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ژورنال
عنوان ژورنال: Free Radical Biology and Medicine
سال: 2016
ISSN: 0891-5849
DOI: 10.1016/j.freeradbiomed.2016.05.010